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KMID : 0545120070170071134
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Journal of Microbiology and Biotechnology
2007 Volume.17 No. 7 p.1134 ~ p.1138
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Inhibitory Effects of Cordycepin (3’-Deoxyadenosine), a Component of Cordyceps militaris, on Human Platelet Aggregation Induced by Thapsigargin
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Cho Hyun-Jeong
Cho Jae-Youl
Rhee Man-Hee
Kim Hyeong-Soo
Lee Hyun-Sub
Park Hwa-Jin
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Abstract
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Cordycepin (3’-deoxyadenosine) is an adenosine analog, isolated from Cordyceps militaris, and it has been used as an anticancer and anti-inflammation ingredient in traditional Chinese medicine. We investigated the effects of cordycepin (3’-deoxyadenosine) on human platelet aggregation, which was induced by thapsigargin, a tumor promoter, and determined the cytosolic free Ca2+ levels ([Ca2+]i) (an aggregationstimulating molecule) and cyclic-guanosine monophosphate (cGMP) (an aggregation-inhibiting molecule). Cordycepin inhibited thapsigargin-induced platelet aggregation in a dosedependent manner, and it clearly reduced the levels of [Ca2+]i, which was increased by thapsigargin (1 μM) or U46619 (3 μM). Cordycepin also increased the thapsigargin-reduced cGMP levels. Accordingly, our data demonstrated that cordycepin may have a beneficial effect on platelet aggregation-mediated thrombotic diseases through the [Ca2+]i-regulating system such as cGMP.
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KEYWORD
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Cordycepin, intracellular Ca2+, cGMP, antiplatelet activity
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